Tnfrsf14^tm1.1Kro
Targeted Allele Detail

Summary

• Symbol: Tnfrsf14^tm1.1Kro
• Name: tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator); targeted mutation 1.1, Mitchell Kronenberg
• MGI ID: MGI:5907516
• Synonyms: Hvem^fl
• Gene: Tnfrsf14 Location: Chr4:155006390-155013020 bp, - strand Genetic Position: Chr4, 85.81 cM
• Alliance: Tnfrsf14^tm1.1Kro page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:243038
• Parent Cell Line: C2 (Nagy) (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The targeting vector contains an FRT-flanked splice acceptor/IRES/lacZ/puromycin fusion gene followed by a loxP site inserted upstream of exon 3 and a second loxP site followed by an F3-flanked neomycin cassette inserted downstream of exon 6. Flp-mediated recombination removed the FRT-flanked lacz/puro and neo cassettes leaving exons 3 through 6 floxed. (J:266163)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tnfrsf14 Mutation: 20 strains or lines available

References

• Original: J:243038 Edwards RG, et al., Murine Corneal Inflammation and Nerve Damage After Infection With HSV-1 Are Promoted by HVEM and Ameliorated by Immune-Modifying Nanoparticle Therapy. Invest Ophthalmol Vis Sci. 2017 Jan 01;58(1):282-291
• All: 6 reference(s)