Rfx1^tm1.1Wrth
Targeted Allele Detail

Summary

• Symbol: Rfx1^tm1.1Wrth
• Name: regulatory factor X, 1 (influences HLA class II expression); targeted mutation 1.1, Walter Reith
• MGI ID: MGI:5907528
• Synonyms: Rfx1^flox
• Gene: Rfx1 Location: Chr8:84793463-84823621 bp, + strand Genetic Position: Chr8, 40.28 cM
• Alliance: Rfx1^tm1.1Wrth page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:227631
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exon 10 was flanked with loxP sites and an FRT flanked neo cassette was inserted in intron 10 via homologous recombination. Flp mediated recombination removed the neo cassette. (J:227631)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rfx1 Mutation: 46 strains or lines available

References

• Original: J:227631 Elkon R, et al., RFX transcription factors are essential for hearing in mice. Nat Commun. 2015;6:8549
• All: 1 reference(s)