Mlx^tm1.2Rne
Targeted Allele Detail

Summary

• Symbol: Mlx^tm1.2Rne
• Name: MAX-like protein X; targeted mutation 1.2, Robert N Eisenman
• MGI ID: MGI:5907738
• Synonyms: Mlx KO
• Gene: Mlx Location: Chr11:100978116-100983033 bp, + strand Genetic Position: Chr11, 64.18 cM, cytoband D
• Alliance: Mlx^tm1.2Rne page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:227117
• Parent Cell Line: AK7.1 (ES Cell)
• Strain of Origin: 129S4/SvJaeSor

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 3 and a loxP site and FRT flanked neomycin cassette were inserted downstream of exon 6 via homologous recombination. FLP- and Cre-mediated recombination removed exons 3-6 and the neomycin selection cassette. No protein is detected in tissues from homozygous mice. (J:243111)

Disease models

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mlx Mutation: 19 strains or lines available

References

• Original: J:227117 Hunt LC, et al., The glucose-sensing transcription factor MLX promotes myogenesis via myokine signaling. Genes Dev. 2015 Dec 1;29(23):2475-89
• All: 3 reference(s)