Esr2^{tm1.1(icre)Jako}
Targeted Allele Detail

Summary

• Symbol: Esr2^{tm1.1(icre)Jako}
• Name: estrogen receptor 2 (beta); targeted mutation 1.1, CheMyong Ko
• MGI ID: MGI:5907833
• Synonyms: Esr2-iCre
• Gene: Esr2 Location: Chr12:76167193-76224033 bp, - strand Genetic Position: Chr12, 33.52 cM, cytoband D1-D3
• Alliance: Esr2^{tm1.1(icre)Jako} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:229096
• Parent Cell Line: PRX-B6N (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Esr2^{tm1.1(icre)Jako} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Esr2 (MGI:109392)

• Mutation details: A targeting vector containing iCre (codon-improved Cre recombinase), a polyadenylation sequence, and an FRT site flanked PGK-NEO cassette was inserted into the initiation codon site of exon 2 of the targeted gene. Flp-mediated recombination removed the FRT-flanked neo cassette. (J:229096)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Esr2 (mouse) Summary of all recombinase alleles driven by Esr2. Alliance mouse Esr2 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Esr2 Mutation: 36 strains or lines available

References

• Original: J:229096 Cacioppo JA, et al., Generation of an estrogen receptor beta-iCre knock-in mouse. Genesis. 2016 Jan;54(1):38-52
• All: 6 reference(s)