Tg(CD2-Cxcr3)833Arsa
Transgene Detail
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Symbol: |
Tg(CD2-Cxcr3)833Arsa |
Name: |
transgene insertion 833, Abhay Satoskar |
MGI ID: |
MGI:5907840 |
Synonyms: |
CXCR3Tg |
Transgene: |
Tg(CD2-Cxcr3)833Arsa Location: unknown
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Alliance: |
Tg(CD2-Cxcr3)833Arsa page
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Transgene Type: |
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Transgenic (Inserted expressed sequence) |
Mutation: |
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Insertion
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Tg(CD2-Cxcr3)833Arsa expresses
1 gene
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Mutation details: The transgenic construct contains mouse cDNA containing Cxcr3 inserted into the second exon of and therefore under the control of the hCD2 minigene, which consists of human CD2 gene promoter and exon 1 with a mutant ATG start codon, first intron, 3' UTR polyA signal, and flanking sequence. Flow cytometric analyis in thymus, lymph nodes, and spleen confirms that protein is expressed constitutively in almost all T cells.
(J:242971)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Original: |
J:242971 Oghumu S, et al., Transgenic expression of CXCR3 on T cells enhances susceptibility to cutaneous Leishmania major infection by inhibiting monocyte maturation and promoting a Th2 response. Infect Immun. 2015 Jan;83(1):67-76 |
All: |
2 reference(s) |
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