Kcnt2^tm1.2Clin
Targeted Allele Detail

Summary

• Symbol: Kcnt2^tm1.2Clin
• Name: potassium channel, subfamily T, member 2; targeted mutation 1.2, Christopher J Lingle
• MGI ID: MGI:5908119
• Gene: Kcnt2 Location: Chr1:140173896-140539805 bp, + strand Genetic Position: Chr1, 61.62 cM
• Alliance: Kcnt2^tm1.2Clin page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:228059
• Parent Cell Line: B6/BLU (ES Cell)
• Strain of Origin: C57BL/6NTac-Tg(HBB-lacZ)ALey/Ley

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: targeting vector was designed to insert a loxP site upstream of exon 22 and a second loxP site downstream of exon22, followed by an FRT-flanked neomycin resistance (neo) cassette which includes a third loxP site. Recombinase-mediated recombination removed the FRT-flanked neo cassette and exon 22. (J:228059)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kcnt2 Mutation: 111 strains or lines available

References

• Original: J:228059 Martinez-Espinosa PL, et al., Knockout of Slo2.2 enhances itch, abolishes KNa current, and increases action potential firing frequency in DRG neurons. Elife. 2015;4:e10013
• All: 3 reference(s)