Tph2^{em1(dre)Ionsz}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Tph2^{em1(dre)Ionsz}
• Name: tryptophan hydroxylase 2; endonuclease-mediated mutation 1, Qiang Sun
• MGI ID: MGI:5908148
• Synonyms: Tph2-Dre
• Gene: Tph2 Location: Chr10:114914546-115020927 bp, - strand Genetic Position: Chr10, 63.51 cM
• Alliance: Tph2^{em1(dre)Ionsz} page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Recombinase)
• Mutation: Insertion
• Tph2^{em1(dre)Ionsz} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Tph2 (MGI:2651811)

• Mutation details: CRISPR/Cas9-system was used to introduce a 2A sequence and dre recombinase just behind the last exon. (J:223507)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Tph2 (mouse) Summary of all recombinase alleles driven by Tph2. Alliance mouse Tph2 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tph2 Mutation: 43 strains or lines available

References

• Original: J:223507 Li Y, et al., Direct data submission for endonuclease mediated alleles from the Institute of Neuroscience, Chinese Academy of Sciences. MGI Direct Data Submission. 2015
• All: 1 reference(s)