Gja10^{tm1.1(icre)Aah}
Targeted Allele Detail

Summary

• Symbol: Gja10^{tm1.1(icre)Aah}
• Name: gap junction protein, alpha 10; targeted mutation 1.1, Arlene Hirano
• MGI ID: MGI:5908159
• Synonyms: Cx57-iCre
• Gene: Gja10 Location: Chr4:32596960-32602760 bp, - strand Genetic Position: Chr4, 14.25 cM
• Alliance: Gja10^{tm1.1(icre)Aah} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:240232
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutations: Insertion, Intragenic deletion
• Gja10^{tm1.1(icre)Aah} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Gja10 (MGI:1339969)

• Mutation details: The protein-coding region of the mouse Gja10 gene was replaced with a FRT flanked neo cassette and an in-frame, icre recombinase gene. Subsequent flp mediated recombination removed the neo cassette and brought the cre recombinase under the control of the endogenous gene promoter. (J:240232)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Gja10 (mouse) Summary of all recombinase alleles driven by Gja10. Comparative matrix view of recombinase activities Alliance mouse Gja10 gene page

Expression

In Mice Carrying this Mutation:

9 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gja10 Mutation: 24 strains or lines available

References

• Original: J:240232 Hirano AA, et al., Targeted Deletion of Vesicular GABA Transporter from Retinal Horizontal Cells Eliminates Feedback Modulation of Photoreceptor Calcium Channels. eNeuro. 2016 Mar-Apr;3(2):ENEURO.0148-15.2016
• All: 8 reference(s)