Tg(Myh6-POLG*Y955C)DWcc
Transgene Detail

Summary

• Symbol: Tg(Myh6-POLG*Y955C)DWcc
• Name: transgene insertion D, William C Copeland
• MGI ID: MGI:5908193
• Synonyms: Y955C TG
• Transgene: Tg(Myh6-POLG*Y955C)DWcc Location: unknown
• Alliance: Tg(Myh6-POLG*Y955C)DWcc page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Myh6-POLG*Y955C)DWcc expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  POLG (5428)

  Polg	(MGI:1196389)

• Mutation details: The human cDNA containing the Y955C mutation seen in patients with chronic progressive external ophthalmoplegia is under the control of the alpha-myosin heavy chain promoter. Four lines were established: B, C, D and E. Line D is entered as the representative line. (J:122507)

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:122507 Lewis W, et al., Decreased mtDNA, oxidative stress, cardiomyopathy, and death from transgenic cardiac targeted human mutant polymerase gamma. Lab Invest. 2007 Apr;87(4):326-35
• All: 2 reference(s)