Tacr1^{tm1.1(cre/ERT2)Sros}
Targeted Allele Detail

Summary

• Symbol: Tacr1^{tm1.1(cre/ERT2)Sros}
• Name: tachykinin receptor 1; targeted mutation 1.1, Sarah E Ross
• MGI ID: MGI:5908273
• Synonyms: NK1R-CreER
• Gene: Tacr1 Location: Chr6:82379315-82537085 bp, + strand Genetic Position: Chr6, 35.94 cM, cytoband D1
• Alliance: Tacr1^{tm1.1(cre/ERT2)Sros} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:237538
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Inducible, Null/knockout, Recombinase)
• Inducer: tamoxifen
• Mutations: Insertion, Intragenic deletion
• Tacr1^{tm1.1(cre/ERT2)Sros} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Tacr1 (MGI:98475)

• Mutation details: The coding region of Tacr1 in exon2 was replaced by a cre/ERT2 cassette and a loxP-flanked neo selection cassette by homologous recombination in ES cells. Correctly targeted ES cell clones were injected into C57BL/6 blastocysts. The neo-cassette was deleted by Cre-mediated excision. (J:237538)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Tacr1 (mouse) Summary of all recombinase alleles driven by Tacr1. Comparative matrix view of recombinase activities Alliance mouse Tacr1 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tacr1 Mutation: 40 strains or lines available

References

• Original: J:237538 Huang H, et al., Generation of a NK1R-CreER knockin mouse strain to study cells involved in Neurokinin 1 Receptor signaling. Genesis. 2016 Nov;54(11):593-601
• All: 6 reference(s)