Tg(Myh6-EGFR*)9-12Iko
Transgene Detail

Summary

• Symbol: Tg(Myh6-EGFR*)9-12Iko
• Name: transgene insertion 9-12, Issei Komuro
• MGI ID: MGI:5908353
• Synonyms: EGFRdn
• Transgene: Tg(Myh6-EGFR*)9-12Iko Location: unknown
• Alliance: Tg(Myh6-EGFR*)9-12Iko page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA/2)F1

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Myh6-EGFR*)9-12Iko expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  EGFR (1956)

  Egfr	(MGI:95294)

  C-terminal truncation

• Mutation details: The alpha myosin heavy chain promoter drives the expression of a truncated human EGFR cDNA in which the C-terminal 533 amino acids are deleted by introduction of a stop codon (TGA) after the R677 codon. Two lines, 2-5 and 9-12, were generated. (J:182337)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:182337 Fukushima N, et al., A crucial role of activin A-mediated growth hormone suppression in mouse and human heart failure. PLoS One. 2011;6(12):e27901
• All: 1 reference(s)