Gt(ROSA)26Sor^{tm2(CARD11*L225LI)Jrld}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm2(CARD11*L225LI)Jrld}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 2, Jurgen Ruland
• MGI ID: MGI:5908402
• Synonyms: CARD11(L225LI)^stopFL
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm2(CARD11*L225LI)Jrld} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:228288
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, Constitutively active, Epitope tag, Humanized sequence, Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm2(CARD11*L225LI)Jrld} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  CARD11 (84433)

  Card11

  (MGI:1916978)

  isoleucine insertion after the leucine at position 225

• Mutation details: A construct containing a slice acceptor site, floxed-neo-stop cassette, HA-tagged human CARD11 cDNA with an isoleucine codon after the leucine codon at position 225 (L225LI), IRES-eGFP cassette and polyA sequence was inserted in intron 1. The human cDNA was derived from a diffuse large B-cell lymphoma and carries a constitutively active mutation. (J:228288)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 993 strains or lines available

References

• Original: J:228288 Knies N, et al., Lymphomagenic CARD11/BCL10/MALT1 signaling drives malignant B-cell proliferation via cooperative NF-kappaB and JNK activation. Proc Natl Acad Sci U S A. 2015 Dec 29;112(52):E7230-8
• All: 2 reference(s)