Tg(Myh6-Mybpc3*)32Rbns
Transgene Detail

Summary

• Symbol: Tg(Myh6-Mybpc3*)32Rbns
• Name: transgene insertion 32, Jeffrey Robbins
• MGI ID: MGI:5908459
• Synonyms: MyBP-C.mut1
• Transgene: Tg(Myh6-Mybpc3*)32Rbns Location: unknown
• Alliance: Tg(Myh6-Mybpc3*)32Rbns page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Myh6-Mybpc3*)32Rbns expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Mybpc3 (MGI:102844)	truncation lacking the myosin and titin protein binding domains

• Mutation details: The mouse cardiac truncated protein lacking both the myosin and titin protein binding domains is under the control of the mouse alpha-myosin heavy chain promoter. Western blot analysis confirmed expression of the truncated protein. The truncated protein shows aberrant incorporation into sarcomeres. Five lines were generated: 21, 33, 31, 32, and 15. This is one of the high expressing lines, showing over 6-fold expression levels. (J:50237)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:50237 Yang Q, et al., A mouse model of myosin binding protein C human familial hypertrophic cardiomyopathy. J Clin Invest. 1998 Oct 1;102(7):1292-300
• All: 3 reference(s)