Tg(Myh6-MYL2*E22K)4Dsc
Transgene Detail
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Symbol: |
Tg(Myh6-MYL2*E22K)4Dsc |
Name: |
transgene insertion 4, Danuta Szczesna-Cordary |
MGI ID: |
MGI:5908892 |
Synonyms: |
Tg-E22K |
Transgene: |
Tg(Myh6-MYL2*E22K)4Dsc Location: unknown
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Alliance: |
Tg(Myh6-MYL2*E22K)4Dsc page
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Strain of Origin: |
Not Specified
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Transgene Type: |
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Transgenic (Humanized sequence, Inserted expressed sequence) |
Mutation: |
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Insertion
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Tg(Myh6-MYL2*E22K)4Dsc expresses
1 gene
Transgene expresses:
Organism |
Expressed Gene |
Homolog in Mouse |
Note |
human |
MYL2 (4633) |
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Mutation details: The mouse cardiac alpha myosin heavy chain promoter along with the first two exons and part of the third drives the cardiac-specific expression of a mutated human myosin regulatory light chain 2 cDNA that contains an amino acid substitution of lysine for glutamic acid at position 22 (E22K, a familial hypertrophic cardiomyopathy-linked mutation). An N-terminal myc sequence was added to aid in identification of the human transgenic protein. Two lines were generated, L2 and L4. Line 4 is entered as the representative line.
(J:101467)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Original: |
J:101467 Szczesna-Cordary D, et al., The E22K mutation of myosin RLC that causes familial hypertrophic cardiomyopathy increases calcium sensitivity of force and ATPase in transgenic mice. J Cell Sci. 2005 Aug 15;118(Pt 16):3675-83 |
All: |
4 reference(s) |
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