Ostn^tm1.1Geno
Targeted Allele Detail

Summary

• Symbol: Ostn^tm1.1Geno
• Name: osteocrin; targeted mutation 1.1, Genoway
• MGI ID: MGI:5908915
• Gene: Ostn Location: Chr16:27126239-27169962 bp, + strand Genetic Position: Chr16, 18.88 cM
• Alliance: Ostn^tm1.1Geno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:228285
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2 was flanked with loxP sites and an FRT flanked neo cassette was inserted via homologous recombination. Cre meditated recombination removed exon 2. Western blot analysis confirmed the absence of protein expression in skeletal muscle from homozygous mice. (J:228285)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ostn Mutation: 14 strains or lines available

References

• Original: J:228285 Subbotina E, et al., Musclin is an activity-stimulated myokine that enhances physical endurance. Proc Natl Acad Sci U S A. 2015 Dec 29;112(52):16042-7
• All: 2 reference(s)