Tg(Myh6-MYL3*)#Dsc
Transgene Detail

Summary

• Symbol: Tg(Myh6-MYL3*)#Dsc
• Name: transgene insertion, Danuta Szczesna-Cordary
• MGI ID: MGI:5909252
• Synonyms: Tg-delta43
• Transgene: Tg(Myh6-MYL3*)#Dsc Location: unknown
• Alliance: Tg(Myh6-MYL3*)#Dsc page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Myh6-MYL3*)#Dsc expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  MYL3 (4634)

  Myl3	(MGI:97268)

  43-amino acid N-terminal truncation

• Mutation details: The human ventricular myosin essential light chain cDNA with a 43-amino acid N-terminal truncation is under the control of the mouse alpha-myosin heavy chain promoter, including the first two exons and part of the third. The truncated protein is similar in sequence to the short MYL3 present in skeletal muscle. Multiple lines were generated (L2, L4, L5, L7, L8, and L9), however, the pound symbol (#) is used when line is not specified and/or lines are pooled. (J:195614)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:195614 Kazmierczak K, et al., The role of the N-terminus of the myosin essential light chain in cardiac muscle contraction. J Mol Biol. 2009 Apr 3;387(3):706-25
• All: 5 reference(s)