Tg(Myh6-Tnni3*R193H)42Xhu
Transgene Detail

Summary

• Symbol: Tg(Myh6-Tnni3*R193H)42Xhu
• Name: transgene insertion 42, Xupei Huang
• MGI ID: MGI:5909303
• Synonyms: cTnI^193His
• Transgene: Tg(Myh6-Tnni3*R193H)42Xhu Location: unknown
• Alliance: Tg(Myh6-Tnni3*R193H)42Xhu page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Myh6-Tnni3*R193H)42Xhu expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Tnni3 (MGI:98783)	corresponds to the human R192H mutation in restrictive cardiomyopathy

• Mutation details: The mouse alpha-myosin heavy chain promoter drives the expression of the mouse cardiac troponin I containing an arginine to histidine change in the C-terminus at residue 193 (R193H), which corresponds to the R192H point mutation linked to restrictive cardiomyopathy in humans. (J:119991)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:119991 Du J, et al., A point mutation (R192H) in the C-terminus of human cardiac troponin I causes diastolic dysfunction in transgenic mice. Arch Biochem Biophys. 2006 Dec 15;456(2):143-50
• All: 6 reference(s)