Tg(Myh6-Tnni3*R146G)121Rbns
Transgene Detail

Summary

• Symbol: Tg(Myh6-Tnni3*R146G)121Rbns
• Name: transgene insertion 121, Jeffrey Robbins
• MGI ID: MGI:5909328
• Synonyms: TnI^146Gly
• Transgene: Tg(Myh6-Tnni3*R146G)121Rbns Location: unknown
• Alliance: Tg(Myh6-Tnni3*R146G)121Rbns page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Myh6-Tnni3*R146G)121Rbns expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Tnni3 (MGI:98783)	corresponds to the human R145G mutation in familial hypertrophic cardiomyopathy

• Mutation details: The murine alpha-myosin heavy chain promoter drives the expression of the mouse troponin I with an arginine to glycine substitution at residue 146 (R146G) in the inhibitory domain which corresponds to the R145G mutation in familial hypertrophic cardiomyopathy in humans. Four lines were generated and two, lines 121 and 133, were analyzed. RNA overexpression levels for line 121 is 1.2-fold higher compared to endogenous RNA. (J:243628)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:243628 James J, et al., Transgenic modeling of a cardiac troponin I mutation linked to familial hypertrophic cardiomyopathy. Circ Res. 2000 Oct 27;87(9):805-11
• All: 3 reference(s)