Tg(Myh6/tetO-Mybpc3*)#Rbns
Transgene Detail
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Symbol: |
Tg(Myh6/tetO-Mybpc3*)#Rbns |
Name: |
transgene insertion, Jeffrey Robbins |
MGI ID: |
MGI:5909970 |
Transgene: |
Tg(Myh6/tetO-Mybpc3*)#Rbns Location: unknown
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Alliance: |
Tg(Myh6/tetO-Mybpc3*)#Rbns page
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Strain of Origin: |
Not Specified
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Transgene Type: |
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Transgenic (Inducible, Inserted expressed sequence) |
Inducer: |
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doxycycline/tetracycline |
Mutation: |
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Insertion
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Tg(Myh6/tetO-Mybpc3*)#Rbns expresses
1 gene
Transgene expresses:
Organism |
Expressed Gene |
Note |
Not Specified |
Mybpc3 |
40-kDa N-terminal fragment |
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Mutation details: This transgene contains a 40-kDa N-terminal fragment of Mybpc3 (amino acids 1-271, containing the C0 domain, a Pro/Ala-rich region, the C1 domain, and 17 residues of the M domain) under the transcriptional control of a mouse alpha-myosin heavy chain promoter fused to the tetracycline-response element (tetO). An N-terminal c-myc tag encoding the human c-myc peptide was inserted after the initiation methionine codon to differentiate transgenic protein from the endogenous one. Some leakage in the expression of the 40-kDa fragment is seen. Multiple lines were generated, however the pound (#) symbol is used because line number is not specified.
(J:213370)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Original: |
J:213370 Razzaque MA, et al., An endogenously produced fragment of cardiac myosin-binding protein C is pathogenic and can lead to heart failure. Circ Res. 2013 Aug 16;113(5):553-61 |
All: |
2 reference(s) |
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