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Tg(Myh6/tetO-Mybpc3*)#Rbns
Transgene Detail
Summary
Symbol: Tg(Myh6/tetO-Mybpc3*)#Rbns
Name: transgene insertion, Jeffrey Robbins
MGI ID: MGI:5909970
Transgene: Tg(Myh6/tetO-Mybpc3*)#Rbns  Location: unknown  
Alliance: Tg(Myh6/tetO-Mybpc3*)#Rbns page
Transgene
origin
Strain of Origin:  Not Specified
Transgene
description
Transgene Type:    Transgenic (Inducible, Inserted expressed sequence)
Inducer:    doxycycline/tetracycline
Mutation:    Insertion
 
Tg(Myh6/tetO-Mybpc3*)#Rbns expresses 1 gene
 
Mutation detailsThis transgene contains a 40-kDa N-terminal fragment of Mybpc3 (amino acids 1-271, containing the C0 domain, a Pro/Ala-rich region, the C1 domain, and 17 residues of the M domain) under the transcriptional control of a mouse alpha-myosin heavy chain promoter fused to the tetracycline-response element (tetO). An N-terminal c-myc tag encoding the human c-myc peptide was inserted after the initiation methionine codon to differentiate transgenic protein from the endogenous one. Some leakage in the expression of the 40-kDa fragment is seen. Multiple lines were generated, however the pound (#) symbol is used because line number is not specified. (J:213370)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:213370 Razzaque MA, et al., An endogenously produced fragment of cardiac myosin-binding protein C is pathogenic and can lead to heart failure. Circ Res. 2013 Aug 16;113(5):553-61
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory