Cdc42ep4^tm1.1Ksh
Targeted Allele Detail

Summary

• Symbol: Cdc42ep4^tm1.1Ksh
• Name: CDC42 effector protein 4; targeted mutation 1.1, Makoto Kinoshita
• MGI ID: MGI:5910399
• Synonyms: Cdc42ep4^-
• Gene: Cdc42ep4 Location: Chr11:113617676-113642707 bp, - strand Genetic Position: Chr11, 79.22 cM, cytoband E2
• Alliance: Cdc42ep4^tm1.1Ksh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:228294
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of the coding region and an FRT flanked inverted neo cassette and loxP site were inserted at the end of the coding region via homologous recombination. Cre-mediated recombination removed the coding region and the neo cassette. Western blot and immunofluorescence analysis confirmed the absence of expression in brains from homozygous mice. (J:228294)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cdc42ep4 Mutation: 36 strains or lines available

References

• Original: J:228294 Ageta-Ishihara N, et al., A CDC42EP4/septin-based perisynaptic glial scaffold facilitates glutamate clearance. Nat Commun. 2015;6:10090
• All: 2 reference(s)