Gsdmd^em1Flv
Endonuclease-mediated Allele Detail

Summary

• Symbol: Gsdmd^em1Flv
• Name: gasdermin D; endonuclease-mediated mutation 1, Richard Flavell
• MGI ID: MGI:5910442
• Gene: Gsdmd Location: Chr15:75734176-75739257 bp, + strand Genetic Position: Chr15, 35.0 cM, cytoband D3-E1
• Alliance: Gsdmd^em1Flv page

Mutation origin

• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exon 2 through part of exon 8 were deleted using sgRNAs and CRIPSR-Cas9 methods. qRT-PCR validation using intestine tissues showed that no detectable full length trasnscript is expressed from this allele. (J:243487)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gsdmd Mutation: 32 strains or lines available

References

• Original: J:243487 Zhu S, et al., Nlrp9b inflammasome restricts rotavirus infection in intestinal epithelial cells. Nature. 2017 Jun 29;546(7660):667-670
• All: 2 reference(s)