Tg(Myh6-Tnni3*L184)#Rste
Transgene Detail

Summary

• Symbol: Tg(Myh6-Tnni3*L184)#Rste
• Name: transgene insertion, Robert Stehle
• MGI ID: MGI:5910501
• Synonyms: TG-deltaK184
• Transgene: Tg(Myh6-Tnni3*L184)#Rste Location: unknown
• Alliance: Tg(Myh6-Tnni3*L184)#Rste page

Transgene origin

• Strain of Origin: C57BL/6 x DBA/2

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Myh6-Tnni3*L184)#Rste expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Tnni3 (MGI:98783)

• Mutation details: The murine cardiac troponin I carrying a deletion of a lysine residue at codon 184 in the C-terminal mobile domain is under the control of the murine alpha-myosin heavy chain promoter. More than 90% of the mouse wild-type protein is replaced by the transgenic protein in isolated cardiac myofibrils from transgenic mice. The pound symbol (#) is used when line is not specified and/or lines are pooled. (J:161911)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:161911 Iorga B, et al., Lys184 deletion in troponin I impairs relaxation kinetics and induces hypercontractility in murine cardiac myofibrils. Cardiovasc Res. 2008 Mar 1;77(4):676-86
• All: 1 reference(s)