Erg^tm1.1Iwamo
Targeted Allele Detail

Summary

• Symbol: Erg^tm1.1Iwamo
• Name: ETS transcription factor; targeted mutation 1.1, Masahiro Iwamoto
• MGI ID: MGI:5910506
• Synonyms: Erg^flox
• Gene: Erg Location: Chr16:95160028-95387452 bp, - strand Genetic Position: Chr16, 56.04 cM
• Alliance: Erg^tm1.1Iwamo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:243715
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The targeting vector contains an FRT-flanked neomycin cassette followed by a loxP site upstream of exon 6 and a second loxP site downstream of exon 6. Flp-mediated recombination removed the FRT-flanked neo cassette. (J:243715)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Erg Mutation: 27 strains or lines available

References

• Original: J:243715 Ohta Y, et al., Articular cartilage endurance and resistance to osteoarthritic changes require transcription factor Erg. Arthritis Rheumatol. 2015 Oct;67(10):2679-90
• All: 3 reference(s)