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Ndufa9em1(IMPC)J
Endonuclease-mediated Allele Detail
Summary
Symbol: Ndufa9em1(IMPC)J
Name: NADH:ubiquinone oxidoreductase subunit A9; endonuclease-mediated mutation 1, Jackson
MGI ID: MGI:5910587
Synonyms: Ndufa9-
Gene: Ndufa9  Location: Chr6:126798826-126826107 bp, - strand  Genetic Position: Chr6, 61.92 cM, cytoband F3
Alliance: Ndufa9em1(IMPC)J page
IMPC: Ndufa9 gene page
Ndufa9em1(IMPC)J/Ndufa9em1(IMPC)J mice exhibit embryonic lethality, with embryos recovered at E7.5 but not at E9.5. Embryos are smaller and form a rudimentary egg cylinder but no primitive streak or hallmarks of gastrulation are seen at E7.5.

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Strain of Origin:  C57BL/6NJ
Project Collection: IMPC
Mutation
description
Allele Type:    Endonuclease-mediated (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsThis allele was generated at The Jackson Laboratory by injecting Cas9 RNA and 4 guide sequences AGCTCTTTAGAACTTGACCA, GGACTCACGGGTGCTCCACA, GTATTGACAATGAGTAGGCC and GCCTTAGGAAAAATTACTTT, which resulted in a 416 bp deletion beginning at Chromosome 6 positive strand position 126,840,391 bp and ending after 126,840,806 bp (GRCm38/mm10). This mutation deletes ENSMUSE00000240808 (exon 5) and 274 bp of flanking intronic sequence including the splice acceptor and donor and is predicted to cause a change of amino acid sequence after residue 137 and early truncation 6 amino acids later. (J:188991)
Inheritance:    Not Specified
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Ndufa9 Mutation:  22 strains or lines available
References
Original:  J:188991 The Jackson Laboratory, Alleles produced for the KOMP project by The Jackson Laboratory. MGI Direct Data Submission. 2012;
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory