Ndufa9em1(IMPC)J
Endonuclease-mediated Allele Detail
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Symbol: |
Ndufa9em1(IMPC)J |
Name: |
NADH:ubiquinone oxidoreductase subunit A9; endonuclease-mediated mutation 1, Jackson |
MGI ID: |
MGI:5910587 |
Synonyms: |
Ndufa9- |
Gene: |
Ndufa9 Location: Chr6:126798826-126826107 bp, - strand Genetic Position: Chr6, 61.92 cM, cytoband F3
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Alliance: |
Ndufa9em1(IMPC)J page
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IMPC: |
Ndufa9 gene page |
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Ndufa9em1(IMPC)J/Ndufa9em1(IMPC)J mice exhibit embryonic lethality, with embryos recovered at E7.5 but not at E9.5. Embryos are smaller and form a rudimentary egg cylinder but no primitive streak or hallmarks of gastrulation are seen at E7.5.
Show the 1 phenotype image(s) involving this allele.
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Strain of Origin: |
C57BL/6NJ
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Project Collection: |
IMPC
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Allele Type: |
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Endonuclease-mediated (Null/knockout) |
Mutation: |
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Intragenic deletion
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Mutation details: This allele was generated at The Jackson Laboratory by injecting Cas9 RNA and 4 guide sequences AGCTCTTTAGAACTTGACCA, GGACTCACGGGTGCTCCACA, GTATTGACAATGAGTAGGCC and GCCTTAGGAAAAATTACTTT, which resulted in a 416 bp deletion beginning at Chromosome 6 positive strand position 126,840,391 bp and ending after 126,840,806 bp (GRCm38/mm10). This mutation deletes ENSMUSE00000240808 (exon 5) and 274 bp of flanking intronic sequence including the splice acceptor and donor and is predicted to cause a change of amino acid sequence after residue 137 and early truncation 6 amino acids later.
(J:188991)
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Inheritance: |
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Not Specified |
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View phenotypes and curated references for all genotypes (concatenated display).
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Original: |
J:188991 The Jackson Laboratory, Alleles produced for the KOMP project by The Jackson Laboratory. MGI Direct Data Submission. 2012; |
All: |
5 reference(s) |
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