Setd1atm1c(EUCOMM)Wtsi
Targeted Allele Detail
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Symbol: |
Setd1atm1c(EUCOMM)Wtsi |
Name: |
SET domain containing 1A; targeted mutation 1c, Wellcome Trust Sanger Institute |
MGI ID: |
MGI:5910691 |
Synonyms: |
Setd1afl |
Gene: |
Setd1a Location: Chr7:127376561-127399294 bp, + strand Genetic Position: Chr7, 69.73 cM
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Alliance: |
Setd1atm1c(EUCOMM)Wtsi page
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IMPC: |
Setd1a gene page |
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Mutant Cell Line: |
EPD0027_4_H10 |
Germline Transmission: |
Earliest citation of germline transmission:
J:241974
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Parent Cell Line: |
JM8.N4 (ES Cell)
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Strain of Origin: |
C57BL/6N
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Project Collection: |
EUCOMM
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Allele Type: |
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Targeted (Conditional ready) |
Mutation: |
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Insertion
Vector: L1L2_gt0
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Mutation details: The L1L2_gt0 cassette was inserted at position 127379089 of Chromosome 7 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of the targeted exon(s) at position 127380049. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele was created by flp recombinase expression in mice carrying this allele to remove the lacZ sequence and neo selection cassette, leaving loxP sites flanking the critical exon(s).
(J:241974)
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Original: |
J:241974 Tusi BK, et al., Setd1a regulates progenitor B-cell-to-precursor B-cell development through histone H3 lysine 4 trimethylation and Ig heavy-chain rearrangement. FASEB J. 2015 Apr;29(4):1505-15 |
All: |
5 reference(s) |
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