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Mcur1tm1c(KOMP)Wtsi
Targeted Allele Detail
Summary
Symbol: Mcur1tm1c(KOMP)Wtsi
Name: mitochondrial calcium uniporter regulator 1; targeted mutation 1c, Wellcome Trust Sanger Institute
MGI ID: MGI:5910730
Synonyms: Mcur1fl
Gene: Mcur1  Location: Chr13:43691869-43713667 bp, - strand  Genetic Position: Chr13, 21.6 cM, cytoband A5
Alliance: Mcur1tm1c(KOMP)Wtsi page
IMPC: Mcur1 gene page
Mutation
origin
Mutant Cell Line:  EPD0332_3_A12
Germline Transmission:  Earliest citation of germline transmission: J:235756
Parent Cell Line:  JM8A1.N3 (ES Cell)
Strain of Origin:  C57BL/6N-Atm1Brd
Project Collection: KOMP-CSD
Mutation
description
Allele Type:    Targeted (Conditional ready)
Mutation:    Insertion     Vector: L1L2_Bact_P
 
Mutation detailsThe L1L2_Bact_P cassette was inserted at position 43704214 of Chromosome 13 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon(s) at position 43705613. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele was created by flp recombinase expression in mice carrying this allele to remove the lacZ sequence and neo selection cassette, leaving loxP sites flanking the critical exon(s). (J:235756)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mcur1 Mutation:  20 strains or lines available
References
Original:  J:235756 Tomar D, et al., MCUR1 Is a Scaffold Factor for the MCU Complex Function and Promotes Mitochondrial Bioenergetics. Cell Rep. 2016 May 24;15(8):1673-85
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory