Lexis1^tm1.1Pton
Targeted Allele Detail

Summary

• Symbol: Lexis1^tm1.1Pton
• Name: lipid responsive LXR-induced inhibitor of cholesterol synthesis 1; targeted mutation 1.1, Peter Tontonoz
• MGI ID: MGI:5910740
• Synonyms: LeXis^-
• Gene: Lexis1 Location: Chr4:53205057-53217830 bp, - strand Genetic Position: Chr4, 28.58 cM
• Alliance: Lexis1^tm1.1Pton page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:233670
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The entire coding region was replaced with a FRT-flanked neomycin selection cassette. Targeted mice were crossed with Flp-expressing mice to excise the neo cassette. (J:233670)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lexis1 Mutation: 0 strains or lines available

References

• Original: J:233670 Sallam T, et al., Feedback modulation of cholesterol metabolism by the lipid-responsive non-coding RNA LeXis. Nature. 2016 Jun 2;534(7605):124-8
• All: 2 reference(s)