Tg(Rr438-Runx1)#Mym
Transgene Detail

Summary

• Symbol: Tg(Rr438-Runx1)#Mym
• Name: transgene insertion, Masayuki Yamamoto
• MGI ID: MGI:5911117
• Synonyms: G1-HRD-Runx1, Runx1-Tg, Tg(Gata1-Runx1)#Mym
• Transgene: Tg(Rr438-Runx1)#Mym Location: unknown
• Alliance: Tg(Rr438-Runx1)#Mym page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA/2)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Rr438-Runx1)#Mym expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Runx1 (MGI:99852)

• Mutation details: The transgene construct comprises sequence containing the mouse Gata1 hematopoietic regulatory domain (G1-HRD) (3.9 kb sequence 5' of the IE exon, the IE exon, intron 1 and part of exon 2; the initiation ATG codon in exon 2 was replaced with a NotI restriction site) upstream of the mouse Runx1 gene. This allele drives the transgene only in hematopoietic tissue. (J:117242)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:117242 Yokomizo T, et al., Characterization of GATA-1(+) hemangioblastic cells in the mouse embryo. EMBO J. 2007 Jan 10;26(1):184-96
• All: 5 reference(s)