Tmprss2^{tm1.1(cre/ERT2)Ychen}
Targeted Allele Detail

Summary

• Symbol: Tmprss2^{tm1.1(cre/ERT2)Ychen}
• Name: transmembrane protease, serine 2; targeted mutation 1.1, Yu Chen
• MGI ID: MGI:5911389
• Synonyms: Tmprss2-CreER^T2
• Gene: Tmprss2 Location: Chr16:97365882-97412395 bp, - strand Genetic Position: Chr16, 57.53 cM, cytoband C2
• Alliance: Tmprss2^{tm1.1(cre/ERT2)Ychen} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:243736
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Inducible, Recombinase, Reporter)
• Inducer: tamoxifen
• Mutations: Insertion, Intragenic deletion
• Tmprss2^{tm1.1(cre/ERT2)Ychen} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Tmprss2 (MGI:1354381)

• Mutation details: The targeting construct replaced exon 2 with an FRT-flanked neomycin resistance cassette, an inducible cre recombinase gene (cre/ERT2), and IRES-nlsGFP. Flp-mediated recombination removed the selection cassette. (J:243736)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Tmprss2 (mouse) Summary of all recombinase alleles driven by Tmprss2. Comparative matrix view of recombinase activities Alliance mouse Tmprss2 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tmprss2 Mutation: 55 strains or lines available

References

• Original: J:243736 Gao D, et al., A Tmprss2-CreERT2 Knock-In Mouse Model for Cancer Genetic Studies on Prostate and Colon. PLoS One. 2016;11(8):e0161084
• All: 6 reference(s)