Gabrg3^em1(IMPC)J
Endonuclease-mediated Allele Detail

Summary

• Symbol: Gabrg3^em1(IMPC)J
• Name: gamma-aminobutyric acid type A receptor, subunit gamma 3; endonuclease-mediated mutation 1, Jackson
• MGI ID: MGI:5911525
• Gene: Gabrg3 Location: Chr7:56366213-57036936 bp, - strand Genetic Position: Chr7, 33.48 cM
• Alliance: Gabrg3^em1(IMPC)J page
• IMPC: Gabrg3 gene page

Mutation origin

• Strain of Origin: C57BL/6NJ
• Project Collection: IMPC

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele was generated at The Jackson Laboratory by injecting Cas9 RNA and 4 guide sequences GGAGCTACCAAGGTAAACAC, ATTTAGGGTTGTGTACTCAT, GTTACTGGCAATTTGCAGTG and GCCTGTGTTGTTAGTGGCTG, which resulted in a 621 bp deletion beginning at Chromosome 7 negative strand position 57,323,993 bp and ending after 57,323,373 bp (GRCm38/mm10). This mutation deletes ENSMUSE00000490283 (exon 3) and 553 bp of flanking intronic sequence including the splice acceptor and donor and is predicted to cause a change of amino acid sequence after residue 67 and early truncation 4 amino acids later. (J:188991)
• Inheritance: Not Specified

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Gabrg3 Mutation: 37 strains or lines available

References

• Original: J:188991 The Jackson Laboratory, Alleles produced for the KOMP project by The Jackson Laboratory. MGI Direct Data Submission. 2012
• All: 3 reference(s)