Ythdc2^em2Embrp
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ythdc2^em2Embrp
• Name: YTH domain containing 2; endonuclease-mediated mutation 2, Ramesh Pillai
• MGI ID: MGI:5911568
• Synonyms: KO line #2
• Gene: Ythdc2 Location: Chr18:44961521-45022782 bp, + strand Genetic Position: Chr18, 23.81 cM
• Alliance: Ythdc2^em2Embrp page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: CRISPR/Cas9 technology removed 152 bp encompassing exon 7. Western blot analysis confirmed the absence of protein expression in the testes. (J:243742)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ythdc2 Mutation: 60 strains or lines available

References

• Original: J:243742 Wojtas MN, et al., Regulation of m(6)A Transcripts by the 3'-->5' RNA Helicase YTHDC2 Is Essential for a Successful Meiotic Program in the Mammalian Germline. Mol Cell. 2017 Oct 19;68(2):374-387.e12
• All: 2 reference(s)