Nus1^tm1.1Qrm
Targeted Allele Detail

Summary

• Symbol: Nus1^tm1.1Qrm
• Name: NUS1 dehydrodolichyl diphosphate synthase subunit; targeted mutation 1.1, Qing Robert Miao
• MGI ID: MGI:5911854
• Synonyms: NgBR^fl
• Gene: Nus1 Location: Chr10:52293643-52316279 bp, + strand Genetic Position: Chr10, 26.64 cM
• Alliance: Nus1^tm1.1Qrm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:243753
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2 and a loxP site and FRT-flanked neo cassette were inserted downstream of exon 4 via homologous recombination. Flp-mediated recombination removed the neo cassette. (J:229464, J:243753)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nus1 Mutation: 19 strains or lines available

References

• Original: J:243753 Hu W, et al., Nogo-B receptor deficiency increases liver X receptor alpha nuclear translocation and hepatic lipogenesis through an adenosine monophosphate-activated protein kinase alpha-dependent pathway. Hepatology. 2016 Nov;64(5):1559-1576
• All: 5 reference(s)