Src^inl
Spontaneous Allele Detail

Summary

• Symbol: Src^inl
• Name: Rous sarcoma oncogene; incisor-less
• MGI ID: MGI:5911893
• Synonyms: Src^thl, thl, toothless
• Gene: Src Location: Chr2:157265828-157313758 bp, + strand Genetic Position: Chr2, 78.35 cM
• Alliance: Src^inl page

Mutation origin

• Strain of Origin: 129

Mutation description

• Allele Type: Spontaneous (Null/knockout)
• Mutation: Insertion
• Mutation details: An insertion or duplication of a C nucleotide (coding nucleotide 1159 in transcript NM_009271 or ENSMUST00000092576) was detected in exon 12, resulting in a frameshift and premature stop codon. Immunoblotting failed to detect wild-type protein or the predicted truncated protein in whole brain lysates from homozygous mice. (J:229610)

Disease models

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Src Mutation: 146 strains or lines available

References

• Original: J:229610 Sinai L, et al., Disruption of Src Is Associated with Phenotypes Related to Williams-Beuren Syndrome and Altered Cellular Localization of TFII-I(1,2). eNeuro. 2015 Mar-Apr;2(2):ENEURO.0016-14.2015
• All: 1 reference(s)