Meis2^tm1.2Zkoz
Targeted Allele Detail

Summary

• Symbol: Meis2^tm1.2Zkoz
• Name: Meis homeobox 2; targeted mutation 1.2, Zbynek Kozmik
• MGI ID: MGI:5911948
• Gene: Meis2 Location: Chr2:115693545-115896320 bp, - strand Genetic Position: Chr2, 58.28 cM
• Alliance: Meis2^tm1.2Zkoz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:229604
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6J)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 3 through 6 were floxed and an FRT flanked neo cassette was inserted via homologous recombination. Flp-mediated recombination removed the neo cassette. Cre mediated recombination removed exons 3-6. Western blot analysis confirmed the absence of protein expression in homozygous embryos. (J:229604)

Expression

In Structures Affected by this Mutation:

10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Meis2 Mutation: 29 strains or lines available

References

• Original: J:229604 Machon O, et al., Meis2 is essential for cranial and cardiac neural crest development. BMC Dev Biol. 2015;15:40
• All: 3 reference(s)