Pkn3^tm1Ajmc
Targeted Allele Detail

Summary

• Symbol: Pkn3^tm1Ajmc
• Name: protein kinase N3; targeted mutation 1, Angus JM Cameron
• MGI ID: MGI:5911981
• Gene: Pkn3 Location: Chr2:29967696-29981034 bp, + strand Genetic Position: Chr2, 21.13 cM
• Alliance: Pkn3^tm1Ajmc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:229595
• Parent Cell Line: PRX-B6N (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Exon 2 was replaced with a pgk-neo cassette via homologous recombination. (J:229595)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pkn3 Mutation: 54 strains or lines available

References

• Original: J:229595 Quetier I, et al., Knockout of the PKN Family of Rho Effector Kinases Reveals a Non-redundant Role for PKN2 in Developmental Mesoderm Expansion. Cell Rep. 2016 Jan 26;14(3):440-8
• All: 1 reference(s)