Lrig3^tm1.1Hhed
Targeted Allele Detail

Summary

• Symbol: Lrig3^tm1.1Hhed
• Name: leucine-rich repeats and immunoglobulin-like domains 3; targeted mutation 1.1, Hakan Hedman
• MGI ID: MGI:5911996
• Gene: Lrig3 Location: Chr10:125802088-125851228 bp, + strand Genetic Position: Chr10, 73.66 cM, cytoband D3
• Alliance: Lrig3^tm1.1Hhed page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:242435
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 1 and a neomycin resistance gene cassette and a second loxP site were inserted into intron 1. Exon 1 was deleted through subsequent cre-mediated recombination. Western blots and RT-PCR confirmed the lack of expression from the knockout allele. (J:242435)

Expression

In Mice Carrying this Mutation:	14 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lrig3 Mutation: 64 strains or lines available

References

• Original: J:242435 Hellstrom M, et al., Cardiac hypertrophy and decreased high-density lipoprotein cholesterol in Lrig3-deficient mice. Am J Physiol Regul Integr Comp Physiol. 2016 Jun 01;310(11):R1045-52
• All: 2 reference(s)