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Creld1tm1.1Chlm
Targeted Allele Detail
Summary
Symbol: Creld1tm1.1Chlm
Name: cysteine-rich with EGF-like domains 1; targeted mutation 1.1, Cheryl L Maslen
MGI ID: MGI:5912278
Gene: Creld1  Location: Chr6:113460317-113470304 bp, + strand  Genetic Position: Chr6, 52.77 cM
Alliance: Creld1tm1.1Chlm page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:243757
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 1 and part of intron 1 (1.9 kb total) were deleted by replacement with a self-excising cassette comprising the following elements: a loxP site, the testis-specific angiotensin I converting enzyme (Ace) promoter, the cre recombinase gene, RNA polymerase II, a neomycin resistance gene, and a second loxP site. (J:243757)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 17 assay results
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Creld1 Mutation:  31 strains or lines available
Notes
ES cell line = D15T44
References
Original:  J:243757 Redig JK, et al., Allelic Interaction between CRELD1 and VEGFA in the Pathogenesis of Cardiac Atrioventricular Septal Defects. AIMS Genet. 2014;1(1):1-19
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory