Nedd9^tm1.1Mcda
Targeted Allele Detail

Summary

• Symbol: Nedd9^tm1.1Mcda
• Name: neural precursor cell expressed, developmentally down-regulated gene 9; targeted mutation 1.1, Margaret Clagett-Dame
• MGI ID: MGI:5912392
• Gene: Nedd9 Location: Chr13:41463392-41640836 bp, - strand Genetic Position: Chr13, 20.43 cM
• Alliance: Nedd9^tm1.1Mcda page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:229548
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 3 was replaced with a lacZ gene and a floxed pgk-neo cassette via homologous recombination. Cre mediated recombination removed the neo cassette. Western blot analysis confirmed loss of protein expression in homozygous mice. (J:229548)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nedd9 Mutation: 34 strains or lines available

References

• Original: J:229548 Knutson DC, et al., Mice null for NEDD9 (HEF1) display extensive hippocampal dendritic spine loss and cognitive impairment. Brain Res. 2016 Feb 1;1632:141-55
• All: 1 reference(s)