Tg(tetO-ERBB2*)5BKkw
Transgene Detail

Summary

• Symbol: Tg(tetO-ERBB2*)5BKkw
• Name: transgene insertion 5B, Kwok-Kin Wong
• MGI ID: MGI:5912484
• Synonyms: tet-op-hHER2^YVMA
• Transgene: Tg(tetO-ERBB2*)5BKkw Location: unknown
• Alliance: Tg(tetO-ERBB2*)5BKkw page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inducible, Inserted expressed sequence)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Tg(tetO-ERBB2*)5BKkw expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  ERBB2 (2064)

  Erbb2

  (MGI:95410)

  in-frame AYVM insertion at residue M774

• Mutation details: Seven direct repeats of the tetracycline-operator (tetO) sequence drive inducible expression of the human gene with in-frame AYVM insertion at residue M774 (YVMA used because M774insAYVM and A775insYVMA lead to identical amino acid changes). Two founders were established: 26 (low copy number, high expression levels) and 5B (high copy numbers, low expression levels). (J:143874)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:143874 Perera SA, et al., HER2YVMA drives rapid development of adenosquamous lung tumors in mice that are sensitive to BIBW2992 and rapamycin combination therapy. Proc Natl Acad Sci U S A. 2009 Jan 13;106(2):474-9
• All: 2 reference(s)