Wdr72^tm1.1Jpsi
Targeted Allele Detail

Summary

• Symbol: Wdr72^tm1.1Jpsi
• Name: WD repeat domain 72; targeted mutation 1.1, James P Simmer
• MGI ID: MGI:5913851
• Gene: Wdr72 Location: Chr9:74017608-74190485 bp, + strand Genetic Position: Chr9, 41.06 cM
• Alliance: Wdr72^tm1.1Jpsi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:242792
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Part of exon 2 and intron 2 of the gene (153 bp from the translation start site to the end of the exon, plus the first 130 bp of the intron) was replaced with the lacZ reporter gene containing a mouse nuclear localization signal (NLS), and a loxP site flanked neomycin resistance gene cassette. The neo cassette was removed through subsequent cre-mediated recombination. (J:242792)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Wdr72 Mutation: 61 strains or lines available

References

• Original: J:242792 Wang SK, et al., Critical roles for WDR72 in calcium transport and matrix protein removal during enamel maturation. Mol Genet Genomic Med. 2015 Jul;3(4):302-19
• All: 1 reference(s)