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Tg(C9orf72)500Lpwr
Transgene Detail
Summary
Symbol: Tg(C9orf72)500Lpwr
Name: transgene insertion 500, Laura Ranum
MGI ID: MGI:5919933
Synonyms: C9-500
Transgene: Tg(C9orf72)500Lpwr  Location: unknown  Genetic Position: Chr6, Syntenic
Alliance: Tg(C9orf72)500Lpwr page
Transgene
origin
Strain of Origin:  FVB/NJ
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(C9orf72)500Lpwr expresses 1 gene
 
Mutation detailsThe bacterial artificial chromosome (BAC) clone (002:B7 subclone m5 30 (Chr9:27,527,137-27,625,470 [Human Genome, February 2009, GRCh37/hg19]) contains the full-length human C9orf72 gene with a range (20-1000) of hexanucleotide repeats (GGGGCC; or G4C2) in intron 1a. The BAC has ~52 kbp of transcriptionally-upstream (telomeric) and ~19 kbp of transcriptionally-downstream (centromeric) flanking sequences that contain no other complete loci or confirmed genes. The ~2 kbp of the Mps one binder kinase activator 3B loci (MOB3B) on the BAC does not include the MOB3B ATG initiation site. The BAC does not contain any portion of the neighboring interferon kappa gene (IFNK). The ~2.4 kbp pseudogene CTAGE12P locus is present in the telomeric sequences. Founder line 500 contains one copy of the transgene with approximately 500 repeats. The transgene has integrated on chromosome 6 (114,939,853-114,939,873 [mouse mm10]) resulting in a 20 bp deletion of genomic region in between the identified breakpoints. There are currently no genes annotated in this region. (J:101977, J:239579)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 8 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying Tg(C9orf72)500Lpwr
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:239579 Liu Y, et al., C9orf72 BAC Mouse Model with Motor Deficits and Neurodegenerative Features of ALS/FTD. Neuron. 2016 May 04;90(3):521-34
All:  14 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory