Bcor^tm1.1Vjba
Targeted Allele Detail

Summary

• Symbol: Bcor^tm1.1Vjba
• Name: BCL6 interacting corepressor; targeted mutation 1.1, Vivian J Bardwell
• MGI ID: MGI:5925306
• Synonyms: Bcor^Fl
• Gene: Bcor Location: ChrX:11902979-12026594 bp, - strand Genetic Position: ChrX, 6.83 cM, cytoband A1.2
• Alliance: Bcor^tm1.1Vjba page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:231455
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The targeting vector is designed to insert a loxP site upstream of exon 9. An FRT-flanked neomycin resistance (neo) cassette, followed by a second loxP site was placed downstream of exon 10. Flp-mediated recombination removed the FRT-flanked neo cassette. (J:231455, J:296645)

Disease models

Expression

In Structures Affected by this Mutation:

17 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Bcor Mutation: 22 strains or lines available

References

• Original: J:231455 Cao Q, et al., BCOR regulates myeloid cell proliferation and differentiation. Leukemia. 2016 May;30(5):1155-65
• All: 8 reference(s)