Gt(ROSA)26Sor^{tm1(Bcor*A)Vjba}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1(Bcor*A)Vjba}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Vivian J Bardwell
• MGI ID: MGI:5925311
• Synonyms: Rosa26^LsLmBcorA
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1(Bcor*A)Vjba} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:231455
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, Inserted expressed sequence)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm1(Bcor*A)Vjba} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  Not Specified	Bcor	Bcor splice version A

• Mutation details: A conditional Lox-Stop-Lox myc-tagged Bcor splice version A (mBcorA) expression cassette was inserted into the murine ROSA26 locus. Overexpression can be induced by cre excision of the loxP-flanked stop-cassette (LsL). (J:231455, J:296645)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 993 strains or lines available

References

• Original: J:231455 Cao Q, et al., BCOR regulates myeloid cell proliferation and differentiation. Leukemia. 2016 May;30(5):1155-65
• All: 2 reference(s)