Setd2^{tm1c(NCOM)Mfgc}
Targeted Allele Detail

Summary

• Symbol: Setd2^{tm1c(NCOM)Mfgc}
• Name: SET domain containing 2; targeted mutation 1c, Mammalian Functional Genomics Centre
• MGI ID: MGI:5925367
• Synonyms: Setd2^fl
• Gene: Setd2 Location: Chr9:110361665-110447701 bp, + strand Genetic Position: Chr9, 60.0 cM
• Alliance: Setd2^{tm1c(NCOM)Mfgc} page
• IMPC: Setd2 gene page

Mutation origin

• Mutant Cell Line: M00019_C_361W_D11
• Germline Transmission: Earliest citation of germline transmission: J:243973
• Parent Cell Line: C2 (Tcp) (ES Cell)
• Strain of Origin: C57BL/6N
• Project Collection: NorCOMM

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion Vector: L1L2_MFGC3
• Mutation details: An FRT site, a LacZ reporter gene cassette, a loxP site, a neomycin resistance gene cassette, and a loxP site were inserted into intron 1. An additional loxP site was inserted into intron 2. The lacZ and neo cassettes were removed through flp-mediated recombination, leaving exon 2 floxed. (J:243973)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Setd2 Mutation: 102 strains or lines available

References

• Original: J:243973 Moffitt AB, et al., Enteropathy-associated T cell lymphoma subtypes are characterized by loss of function of SETD2. J Exp Med. 2017 May 01;214(5):1371-1386
• All: 1 reference(s)