Gt(ROSA)26Sor^{tm1(CAG-CAMK2G*T287D,-EGFP)Whua}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1(CAG-CAMK2G*T287D,-EGFP)Whua}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Wendong Huang
• MGI ID: MGI:5927425
• Synonyms: CA-CAMK2gamma fl
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1(CAG-CAMK2G*T287D,-EGFP)Whua} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:243363
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm1(CAG-CAMK2G*T287D,-EGFP)Whua} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  CAMK2G (818)

  Camk2g

  (MGI:88259)

• Mutation details: A conditional human CAMK2G (isoform 3) over-expression cassette containing a T-to-D mutation at Thr287 (T287D) and a loxP-flanked STOP and a frt-flanked IRES-EGFP under the control of the CAG promoter was inserted into the locus. The T287D mutation allows for constitutive activation of the gene. (J:243363)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 993 strains or lines available

References

• Original: J:243363 Ma X, et al., CAMK2gamma in intestinal epithelial cells modulates colitis-associated colorectal carcinogenesis via enhancing STAT3 activation. Oncogene. 2017 Jul 13;36(28):4060-4071
• All: 1 reference(s)