Pias3^tm1.2Asw
Targeted Allele Detail

Summary

• Symbol: Pias3^tm1.2Asw
• Name: protein inhibitor of activated STAT 3; targeted mutation 1.2, Anand Swaroop
• MGI ID: MGI:5927688
• Gene: Pias3 Location: Chr3:96603700-96613386 bp, + strand Genetic Position: Chr3, 41.95 cM
• Alliance: Pias3^tm1.2Asw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:243503
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted into intron 1 and a second loxP site and an FRT site flanked neomycin resistance gene cassette into intron 5. The neo cassette was removed through subsequent flp-mediated recombination. Exons 2-5 were deleted through cre-mediated recombination by crossing these mice with mice carrying the Tg(rx3-icre)1Mjam allele. That allele shows leaky expression in the oocytes, thus creating some non-conditional null mouse lines i this crossing. (J:243503)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pias3 Mutation: 39 strains or lines available

References

• Original: J:243503 Campla CK, et al., Pias3 is necessary for dorso-ventral patterning and visual response of retinal cones but is not required for rod photoreceptor differentiation. Biol Open. 2017 Jun 15;6(6):881-890
• All: 1 reference(s)