Clstn2^tm1Amcr
Targeted Allele Detail

Summary

• Symbol: Clstn2^tm1Amcr
• Name: calsyntenin 2; targeted mutation 1, Ann Marie Craig
• MGI ID: MGI:6093445
• Gene: Clstn2 Location: Chr9:97326448-97915234 bp, - strand Genetic Position: Chr9, 51.06 cM, cytoband E4
• Alliance: Clstn2^tm1Amcr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:248293
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A BAC clone from the 129/S7 bMQ library was used to construct a targeting vector by replacing exon 3 with a loxP site and an FRT site flanked neomycin resistance gene cassette. Western blots confirmed the loss of expression from this null allele. (J:248293)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Clstn2 Mutation: 55 strains or lines available

References

• Original: J:248293 Lipina TV, et al., Cognitive Deficits in Calsyntenin-2-deficient Mice Associated with Reduced GABAergic Transmission. Neuropsychopharmacology. 2016 Feb;41(3):802-10
• All: 3 reference(s)