Ccn6^tm1.1Cgkl
Targeted Allele Detail

Summary

• Symbol: Ccn6^tm1.1Cgkl
• Name: cellular communication network factor 6; targeted mutation 1.1, Celina G Kleer
• MGI ID: MGI:6093469
• Synonyms: Ccn6^fl
• Gene: Ccn6 Location: Chr10:39026966-39039790 bp, - strand Genetic Position: Chr10, 20.19 cM
• Alliance: Ccn6^tm1.1Cgkl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:241259
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: FVB/N

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Approximately a 4.5 kb region, containing exons 2 and 3, was flanked by loxP sites. A frt-flanked neo cassette inserted after exon 3 was removed via Flp-mediated recombination. (J:241259)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ccn6 Mutation: 23 strains or lines available

References

• Original: J:241259 Martin EE, et al., MMTV-cre;Ccn6 knockout mice develop tumors recapitulating human metaplastic breast carcinomas. Oncogene. 2017 Apr 20;36(16):2275-2285
• All: 1 reference(s)