Astn2^ridge
Spontaneous Allele Detail

Summary

• Symbol: Astn2^ridge
• Name: astrotactin 2; ridge
• MGI ID: MGI:6093704
• Synonyms: ridge
• Gene: Astn2 Location: Chr4:65299040-66322774 bp, - strand Genetic Position: Chr4, 34.31 cM, cytoband C1
• Alliance: Astn2^ridge page

Mutation origin

• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Spontaneous (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: The molecular lesion is a a ~30 kb deletion that encompasses exon 5 and has endpoints within a pair of LINE elements. PCR typing showed that the ~30 kb deletion is present in both R1 ES cells and in 129X1/SvJ mice, but not in the closely related 129S1/SvlmJ or 129S6/SvEvTac strains. (J:228899)

Expression

In Mice Carrying this Mutation:

10 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Astn2 Mutation: 61 strains or lines available

References

• Original: J:228899 Chang H, et al., Identification of Astrotactin2 as a Genetic Modifier That Regulates the Global Orientation of Mammalian Hair Follicles. PLoS Genet. 2015 Sep;11(9):e1005532
• All: 1 reference(s)