Pptc7^em1Pagd
Endonuclease-mediated Allele Detail

Summary

• Symbol: Pptc7^em1Pagd
• Name: PTC7 protein phosphatase homolog; endonuclease-mediated mutation 1, David J Pagliarini
• MGI ID: MGI:6094244
• Synonyms: Pptc7E2d4, Pptc7^em1Pag
• Gene: Pptc7 Location: Chr5:122422461-122462344 bp, + strand Genetic Position: Chr5, 62.28 cM
• Alliance: Pptc7^em1Pagd page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR/Cas9 technology introduced a 4 bases (GCGA) deletion within exon 2. (J:276212)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pptc7 Mutation: 48 strains or lines available

References

• Original: J:276212 Niemi NM, et al., CRISPR-mediated knockout of Pptc7 disrupts mitochondrial metabolism. MGI Direct Data Submission. 2019
• All: 2 reference(s)